Kruppel-like factor 8 emerges as an important regulator of cancer

被引：0
|
作者：
Lahiri, Satadru K. [1 ]
Zhao, Jihe [1 ]
机构：
[1] Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2012年 / 4卷 / 03期
关键词：
Kruppel-like factor 8 (KLF8); cancer; FOCAL ADHESION KINASE; CELL-CYCLE PROGRESSION; KLF8; TRANSCRIPTION; IN-VIVO; IDENTIFICATION; GENE; ACTIVATION; EXPRESSION; INVASION; FINGERS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Kruppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.
引用
收藏
页码：357 / 363
页数：7
相关论文
共 50 条
  • [21] Erythroid Kruppel-like factor directly activates the basic Kruppel-like factor gene in erythroid cells
    Funnell, Alister P. W.
    Maloney, Christopher A.
    Thompson, Lucinda J.
    Keys, Janelle
    Tallack, Michael
    Perkins, Andrew C.
    Crossley, Merlin
    MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (07) : 2777 - 2790
  • [22] KRUPPEL-LIKE FACTOR 10 IS A IMPORTANT MODULATORY FACTOR OF CHONDROCYTE HYPERTROPHY IN DEVELOPING SKELETON
    Ko, J. Y.
    Lee, E.
    Kim, J.
    Im, G. I.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1333 - 1333
  • [23] The Kruppel-like factor KLF15 is a novel regulator of cardiomyocyte hypertrophy
    Fisch, Sudeshna
    Gray, Susan J.
    Heymans, Stephane
    Wang, Baioiu
    Haldar, Saptarshi
    Pfister, Otmar
    Cui, Lei
    Kumar, Ajay
    Lin, Zhiyong
    Sen-Banerjee, Sucharita
    Das, Hiranmoy
    Petersen, Christy
    Mende, Ulrike
    Burleigh, Barbara
    Zhu, Yan
    Pinto, Yigal
    Liao, Ronglih
    Jain, Mukesh K.
    CIRCULATION, 2006, 114 (18) : 161 - 162
  • [24] Biology of Kruppel-Like Factor 6 Transcriptional Regulator in Cell Life and Death
    Andreoli, Veronica
    Gehrau, Ricardo C.
    Luis Bocco, Jose
    IUBMB LIFE, 2010, 62 (12) : 896 - 905
  • [25] KRUPPEL-LIKE FACTOR 10 IS A IMPORTANT MODULATORY FACTOR OF CHONDROCYTE HYPERTROPHY IN DEVELOPING SKELETON
    Ko, J. -Y.
    Lee, E.
    Park, J. -W.
    Kim, J.
    Im, G. -I.
    OSTEOARTHRITIS AND CARTILAGE, 2020, 28 : S504 - S505
  • [26] A novel regulator of human villous trophoblast fusion: the Kruppel-like factor 6
    Cristina Racca, Ana
    Evelin Ridano, Magali
    Camolotto, Soledad
    Genti-Raimondi, Susana
    Maria Panzetta-Dutari, Graciela
    MOLECULAR HUMAN REPRODUCTION, 2015, 21 (04) : 347 - 358
  • [27] Downregulation of Kruppel-like factor 9 in human colorectal cancer
    Kang, Ling
    Lue, Bingjian
    Xu, Jing
    Hu, Hu
    lai, Maode
    PATHOLOGY INTERNATIONAL, 2008, 58 (06) : 334 - 338
  • [28] KRUPPEL-LIKE FACTOR 5 PLAYS AN IMPORTANT ROLE IN THE PATHOGENESIS OF CHRONIC PANCREATITIS
    Alavi, Maryam
    Mejia, Ana
    He, Ping
    Bandovic, Jela
    Yang, Vincent W.
    Bialkowska, Agnieszka B.
    GASTROENTEROLOGY, 2019, 156 (06) : S8 - S8
  • [29] Dysregulation of Kruppel-like factor 12 in the development of endometrial cancer
    Ding, Ling
    Ding, Yi
    Kong, Xiangyi
    Wu, Jun
    Fu, Jian
    Yan, Guijun
    Zhou, Huaijun
    GYNECOLOGIC ONCOLOGY, 2019, 152 (01) : 177 - 184
  • [30] The role of Kruppel-like factor 8 in cancer biology: Current research and its clinical relevance
    Kumar, Sanjay
    Behera, Abhijeet
    Saha, Priyanka
    Srivastava, Amit Kumar
    BIOCHEMICAL PHARMACOLOGY, 2021, 183
12345