Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells

被引：29

作者：

Vural, Altugan Cahit ^{[1
]}

Odabas, Sedat ^{[2
]}

Korkusuz, Petek ^{[3
]}

Saglam, Atiye Seda Yar ^{[4
]}

Bilgic, Elif ^{[3
]}

Cavusoglu, Tarik ^{[1
]}

Piskin, Erhan ^{[5
,6
]}

Vargel, Ibrahim ^{[7
]}

机构：

[1] Kirikkale Univ, Fac Med, Dept Plast & Aesthet Surg, Kirikkale, Turkey

[2] Ankara Univ, Dept Chem, Fac Sci, Ankara, Turkey

[3] Hacettepe Univ, Dept Histol & Embryol, Fac Med, Ankara, Turkey

[4] Gazi Univ, Dept Mol Biol & Genet, Fac Med, Ankara, Turkey

[5] Hacettepe Univ, Dept Chem Engn, Ankara, Turkey

[6] Hacettepe Univ, Bioengn Div, Ctr Bioengn Biyomedtek, Ankara, Turkey

[7] Hacettepe Univ, Fac Med, Dept Plast & Aesthet Surg, Ankara, Turkey

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 03期

关键词：

Bone morphogenetic protein-2; cranial bone regeneration; critical size defect; mesenchymal stem cell; transfection; MORPHOGENETIC PROTEIN-2; GROWTH-FACTOR; IN-VIVO; SCAFFOLDS; CRYOGELS; DEFECTS;

D O I：

10.3109/21691401.2016.1160918

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.

引用

页码：544 / 550

页数：7

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