Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines

被引：5
|
作者：
Kamataki, T [1 ]
Suzuki, A
Kushida, H
Iwata, H
Watanabe, M
Nohmi, T
Fujita, K
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Div Pharmacobiodynam, Lab Drug Metab,Kita Ku, Sapporo, Hokkaido 0600812, Japan
[2] Natl Inst Canc Res, Div Biochem, Chuo Ku, Tokyo 1040045, Japan
[3] Natl Inst Hlth Sci, Div Genet & Mutagenesis, Setagaya Ku, Tokyo 1580098, Japan
来源：
CANCER LETTERS | 1999年 / 143卷 / 02期
关键词：
Salmonella tester strain; mutagenic heterocyclic amines;
D O I：
10.1016/S0304-3835(99)00138-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A co-expression plasmid (p1A2OR) carrying human CYP1A2 and NADPH-P450 reductase cDNAs and an expression plasmid (pOAT) carrying Salmonella TA1538/ARO cells. The CYP and OAT expressed in the Salmonella cells showed catalytic activity. The TA1538/ARO strain exhibited high sensitivity to heterocyclic amines (HCAs) such as 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimenthylimidazo[4,5-f]quinoline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as compared with the parent Ames tester strain TA1538. It is suggested that the intracellular expression of drug-metabolising enzymes makes the Salmonella cells highly sensitive to the HCAs. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：113 / 116
页数：4
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