Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers

被引：9

作者：

Kallitsakis, Michael G. ^{[1
]}

Hadjipavlou-Litina, Dimitra J. ^{[2
]}

Litinas, Konstantinos E. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Thessaloniki, Greece

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2013年 / 28卷 / 04期

关键词：

Modified homo-N-nucleosides; purines; coumarins; cross metathesis; microwaves; antioxidant activity; TANDEM CROSS-METATHESIS; INHIBITORS; DERIVATIVES; CHEMISTRY; ANTIOXIDANT; ANALOGS; HIV; LIPOXYGENASE; PHOSPHONATES; COMPLEXES;

D O I：

10.3109/14756366.2012.684050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6-or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.

引用

页码：765 / 775

页数：11

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