Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers

被引：9
|
作者：
Kallitsakis, Michael G. [1 ]
Hadjipavlou-Litina, Dimitra J. [2 ]
Litinas, Konstantinos E. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Thessaloniki, Greece
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2013年 / 28卷 / 04期
关键词：
Modified homo-N-nucleosides; purines; coumarins; cross metathesis; microwaves; antioxidant activity; TANDEM CROSS-METATHESIS; INHIBITORS; DERIVATIVES; CHEMISTRY; ANTIOXIDANT; ANALOGS; HIV; LIPOXYGENASE; PHOSPHONATES; COMPLEXES;
D O I：
10.3109/14756366.2012.684050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cross metathesis (CM) of 9-butenylpurines with 4-butenyloxycoumarin in the presence of Grubbs 2nd generation catalyst under MW irradiation resulted to conjugated compounds containing homo-N-nucleosides and coumarins. Analogous derivatives received by the CM reaction of 9-butenyl-6-piperidinylpurine with 6-or 7-butenyloxycoumarins, allyloxycoumarins or coumarinyl acrylate. These compounds were tested in vitro for their antioxidant activity and they present significant scavenging activity. The presence of a pentenyloxy moiety, the attachment position on coumarin ring as well as a purine homo-N-nucleoside group are considered as important structural features.
引用
收藏
页码：765 / 775
页数：11
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