Recent advances in the heterologous expression of microbial natural product biosynthetic pathways

被引：141

作者：

Ongley, Sarah E. ^{[1
]}

Bian, Xiaoying ^{[2
,3
]}

Neilan, Brett A. ^{[1
]}

Mueller, Rolf ^{[2
,3
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ Saarland, Dept Microbial Nat Prod, Helmholtz Inst Pharmaceut Res Saarland HIPS, Helmholtz Ctr Infect Res HZI, D-66123 Saarbrucken, Germany

[3] Univ Saarland, Dept Pharmaceut Biotechnol, D-66123 Saarbrucken, Germany

来源：

NATURAL PRODUCT REPORTS | 2013年 / 30卷 / 08期

基金：

澳大利亚研究理事会;

关键词：

STREPTOMYCES-COELICOLOR A3(2); TRANSPOSON-BASED STRATEGIES; SYNTHETASE GENE-CLUSTER; ESCHERICHIA-COLI; MYXOCOCCUS-XANTHUS; HOMOLOGOUS RECOMBINATION; POLYKETIDE SYNTHASE; E; COLI; PHOSPHOPANTETHEINYL TRANSFERASE; BACILLUS-SUBTILIS;

D O I：

10.1039/c3np70034h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The heterologous expression of microbial natural product biosynthetic pathways coupled with advanced DNA engineering enables optimisation of product yields, functional elucidation of cryptic gene clusters, and generation of novel derivatives. This review summarises the recent advances in cloning and maintenance of natural product biosynthetic gene clusters for heterologous expression and the efforts fundamental for discovering novel natural products in the post-genomics era, with a focus on polyketide synthases (PKSs) and non-ribosomal polypeptide synthetases (NRPS).

引用

页码：1121 / 1138

页数：18

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