Myeloid-derived suppressor cells and the efficacy of CD8+ T-cell immunotherapy

被引：6
|
作者：
Lesokhin, Alexander M. [1 ]
Merghoub, Taha [1 ]
Wolchok, Jedd D. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 02期
关键词：
CCR2; myeloid derived suppressor cells; GM-CSF; immunotherapy; adoptive T-cell transfer; ANTIGEN; INFILTRATION; CANCER;
D O I：
10.4161/onci.22764
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer.
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页数：3
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