A phase Ib, multicenter, open-label study of the antibody-drug conjugate trastuzumab deruxtecan (DS-8201a) combination with nivolumab for advanced HER2-expressing breast or urothelial cancer

被引:0
|
作者
Hurvitz, S. A. [1 ]
Galsky, M. D. [2 ]
Shahidi, J. [3 ]
Zhang, G. [4 ]
Raza, S. [3 ]
Necchi, A. [5 ]
机构
[1] UCLA Med Ctr, Dept Med, Los Angeles, CA USA
[2] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA
[3] Daiichi Sankyo Inc, Clin Dev, Basking Ridge, NJ USA
[4] Daiichi Sankyo Inc, Biostat & Data Management, Basking Ridge, NJ USA
[5] Fdn IRCCS Ist Nazl Tumori, Med Oncol, Milan, Italy
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
370TiP
引用
收藏
页数:1
相关论文
共 50 条
  • [21] A phase II, multicenter, open-label study of trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): DESTINY-CRC01.
    Siena, Salvatore
    Di Bartolomeo, Maria
    Raghav, Kanwal Pratap Singh
    Masuishi, Toshiki
    Loupakis, Fotios
    Kawakami, Hisato
    Yamaguchi, Kensei
    Nishina, Tomohiro
    Fakih, Marwan
    Elez, Elena
    Rodriguez, Javier
    Ciardiello, Fortunato
    Saxena, Kapil
    Yamamoto, Eriko
    Bako, Emarjola
    Okuda, Yasuyuki
    Shahidi, Javad
    Grothey, Axel
    Yoshino, Takayuki
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [22] A phase III, multicenter, randomized, open label trial of [fam-] trastuzumab deruxtecan (DS-8201a) versus investigator's choice in HER2-low breast cancer.
    Modi, Shanu
    Ohtani, Shoichiro
    Lee, Caleb C.
    Wang, Kongming
    Saxena, Kapil
    Cameron, David A.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [23] Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study
    Tamura, Kenji
    Tsurutani, Junji
    Takahashi, Shunji
    Iwata, Hiroji
    Krop, Ian E.
    Redfern, Charles
    Sagara, Yasuaki
    Doi, Toshihiko
    Park, Haeseong
    Murthy, Rashmi K.
    Redman, Rebecca A.
    Jikoh, Takahiro
    Lee, Caleb
    Sugihara, Masahiro
    Shahidi, Javad
    Yver, Antoine
    Modi, Shanu
    LANCET ONCOLOGY, 2019, 20 (06): : 816 - 826
  • [24] Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study
    Shitara, Kohei
    Iwata, Hiroji
    Takahashi, Shunji
    Tamura, Kenji
    Park, Haeseong
    Modi, Shanu
    Tsurutani, Junji
    Kadowaki, Shigenon
    Yamaguchi, Kensei
    Iwasa, Satoru
    Saito, Kaku
    Fujisaki, Yoshihiko
    Sugihara, Masahiro
    Shahidi, Javad
    Doi, Toshihiko
    LANCET ONCOLOGY, 2019, 20 (06): : 827 - 836
  • [25] Trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): Final results from a phase 2, multicenter, open-label study (DESTINY-CRC01)
    Yoshino, Takayuki
    Di Bartolomeo, Maria
    Raghav, Kanwal Pratap Singh
    Masuishi, Toshiki
    Kawakami, Hisato
    Yamaguchi, Kensei
    Nishina, Tomohiro
    Wainberg, Zev A.
    Elez, Elena
    Rodriguez, Javier
    Fakih, Marwan
    Ciardiello, Fortunato
    Saxena, Kapil
    Kobayashi, Kojiro
    Bako, Emarjola
    Okuda, Yasuyuki
    Meinhardt, Gerold
    Grothey, Axel
    Siena, Salvatore
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (04)
  • [26] Trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): Final results from a phase 2, multicenter, open-label study (DESTINY-CRC01).
    Yoshino, Takayuki
    Di Bartolomeo, Maria
    Raghav, Kanwal Pratap Singh
    Masuishi, Toshiki
    Loupakis, Fotios
    Kawakami, Hisato
    Yamaguchi, Kensei
    Nishina, Tomohiro
    Wainberg, Zev A.
    Elez, Elena
    Rodriguez, Javier
    Fakih, Marwan
    Ciardiello, Fortunato
    Saxena, Kapil
    Kobayashi, Kojiro
    Bako, Emarjola
    Okuda, Yasuyuki
    Meinhardt, Gerold
    Grothey, Axel
    Siena, Salvatore
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [27] Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, demonstrates in vitro and in vivo antitumor activity against primary and metastatic ovarian tumors overexpressing HER2
    Mutlu, Levent
    McNamara, Blair
    Bellone, Stefania
    Manavella, Diego D.
    Demirkiran, Cem
    Greenman, Michelle
    Verzosa, Miguel Skyler Z.
    Buza, Natalia
    Hui, Pei
    Hartwich, Tobias Max Philipp
    Harold, Justin
    Yang-Hartwich, Yang
    Zipponi, Margherita
    Altwerger, Gary
    Ratner, Elena
    Huang, Gloria S.
    Clark, Mitchell
    Andikyan, Vaagn
    Azodi, Masoud
    Schwartz, Peter E.
    Santin, Alessandro D.
    CLINICAL & EXPERIMENTAL METASTASIS, 2024, 41 (05) : 765 - 775
  • [28] Exploratory biomarker analysis of DESTINY-CRC01, a phase II, multicenter, open-label study of trastuzumab deruxtecan (T-DXd, DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC)
    Siena, S.
    Raghav, K.
    Masuishi, T.
    Yamaguchi, K.
    Nishina, T.
    Elez, E.
    Rodriguez, J.
    Chau, I.
    Di Bartolomeo, M.
    Kawakami, H.
    Suto, F.
    Kobayashi, K.
    Koga, M.
    Inaki, K.
    Kuwahara, Y.
    Takehara, I.
    Grothey, A.
    Yoshino, T.
    ANNALS OF ONCOLOGY, 2021, 32 : S532 - S532
  • [29] Trastuzumab deruxtecan (DS-8201a) in subjects with HER2-expressing solid tumors: Long-term results of a large phase 1 study with multiple expansion cohorts.
    Iwata, Hiroji
    Tamura, Kenji
    Doi, Toshihiko
    Tsurutani, Junji
    Modi, Shanu
    Park, Haeseong
    Krop, Ian E.
    Sagara, Yasuaki
    Redfern, Charles H.
    Murthy, Rashmi Krishna
    Redman, Rebecca A.
    Shitara, Kohei
    Fujisaki, Yoshihiko
    Sugihara, Masahiro
    Zhang, Lin
    Shahidi, Javad
    Yver, Antoine
    Takahashi, Shunji
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [30] Primary analysis from DS8201-A-U105: A phase 1b, two-part, open-label study of trastuzumab deruxtecan (T-DXd) with nivolumab (nivo) in patients (pts) with HER2-expressing urothelial carcinoma (UC).
    Galsky, Matt D.
    Del Conte, Gianluca
    Foti, Silvia
    Yu, Evan Y.
    Machiels, Jean-Pascal H.
    Doger, Bernard
    Necchi, Andrea
    De Braud, Filippo G.
    Hamilton, Erika P.
    Hennequin, Audrey
    Van den Mooter, Tom
    Debruyne, Philip R.
    Moreno, Irene
    Arkenau, Hendrik-Tobias
    Tsuchihashi, Zenta
    Cheng, Fu-Chih
    Augustine, Bincy
    Cheng, Ben
    Barrios, Daniel
    Luftner, Diana
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (06)