Does XIST safeguard against sex-biased human diseases?

被引：1
|
作者：
Sado, Takashi [1 ,2 ]
机构：
[1] Kindai Univ, Grad Sch Agr, Dept Adv Biosci, Nara 6318505, Japan
[2] Kindai Univ, Agr Technol & Innovat Res Inst, Nara 6318505, Japan
来源：
MOLECULAR CELL | 2021年 / 81卷 / 08期
关键词：
X-CHROMOSOME; RNA;
D O I：
10.1016/j.molcel.2021.03.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Yu et al. (2021) demonstrate that a subset of X-linked immune genes is repressed on the inactive X chromosome (Xi) in a manner dependent on XIST RNA in B cells, and derepression of these genes upon XIST depletion could bias differentiation of naive B cells and be involved in etiology of female-biased autoimmune diseases.
引用
收藏
页码：1598 / 1600
页数：3
相关论文
共 50 条
  • [21] Sex-biased gene expression
    Grath S.
    Parsch J.
    BIOspektrum, 2019, 25 (1) : 12 - 14
  • [22] IS THERE SEX-BIASED MORTALITY IN PRIMATES
    HAUSER, MD
    HARCOURT, AH
    FOLIA PRIMATOLOGICA, 1992, 58 (01) : 47 - 52
  • [23] Uncovering sex-biased eQTLs
    Mary Muers
    Nature Reviews Genetics, 2012, 13 (11) : 756 - 756
  • [24] Sex-Biased Gene Expression
    Grath, Sonja
    Parsch, John
    ANNUAL REVIEW OF GENETICS, VOL 50, 2016, 50 : 29 - 44
  • [25] EVOLUTION OF SEX-BIASED DISPERSAL
    Trochet, Audrey
    Courtois, Elodie A.
    Stevens, Virginie M.
    Baguette, Michel
    QUARTERLY REVIEW OF BIOLOGY, 2016, 91 (03): : 297 - 320
  • [26] FMD and SCAD Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
    Kim, Esther S. H.
    Saw, Jacqueline
    Kadian-Dodov, Daniella
    Wood, Malissa
    Ganesh, Santhi K.
    CIRCULATION RESEARCH, 2021, 128 (12) : 1958 - 1972
  • [27] Inverted Expression Profiles of Sex-Biased Genes in Response to Toxicant Perturbations and Diseases
    Ung, Choong Yong
    Lam, Siew Hong
    Zhang, Xun
    Li, Hu
    Zhang, Louxin
    Li, Baowen
    Gong, Zhiyuan
    PLOS ONE, 2013, 8 (02):
  • [28] Sex-biased dispersal in a salmonid fish
    Hutchings, JA
    Gerber, L
    PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 269 (1508) : 2487 - 2493
  • [29] Are sex-biased genes more dispensable?
    Mank, Judith E.
    Ellegren, Hans
    BIOLOGY LETTERS, 2009, 5 (03) : 409 - 412
  • [30] RECOGNITION OF SEX-BIASED COUNSELING INTERACTIONS
    ORCUTT, MA
    WALSH, WB
    PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE, 1983, 14 (04) : 462 - 472
12345