Does XIST safeguard against sex-biased human diseases?

被引：1
|
作者：
Sado, Takashi [1 ,2 ]
机构：
[1] Kindai Univ, Grad Sch Agr, Dept Adv Biosci, Nara 6318505, Japan
[2] Kindai Univ, Agr Technol & Innovat Res Inst, Nara 6318505, Japan
来源：
MOLECULAR CELL | 2021年 / 81卷 / 08期
关键词：
X-CHROMOSOME; RNA;
D O I：
10.1016/j.molcel.2021.03.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Yu et al. (2021) demonstrate that a subset of X-linked immune genes is repressed on the inactive X chromosome (Xi) in a manner dependent on XIST RNA in B cells, and derepression of these genes upon XIST depletion could bias differentiation of naive B cells and be involved in etiology of female-biased autoimmune diseases.
引用
收藏
页码：1598 / 1600
页数：3
相关论文
共 50 条
  • [1] Implicating XIST in sex-biased autoimmunity
    Vogan, Kyle
    NATURE GENETICS, 2024, 56 (03) : 357 - 357
  • [2] Xist ribonucleoproteins promote female sex-biased autoimmunity
    Dou, Diana R.
    Zhao, Yanding
    Belk, Julia A.
    Zhao, Yang
    Casey, Kerriann M.
    Li, Rui
    Chen, Derek C.
    Yu, Bingfei
    Srinivasan, Suhas
    Abe, Brian T.
    Kraft, Katerina
    Hellstrom, Ceke
    Sjoberg, Ronald
    Chang, Sarah
    Feng, Allan
    Goldman, Daniel W.
    Shah, Ami A.
    Petri, Michelle
    Chung, Lorinda S.
    Fiorentino, David F.
    Lundberg, Emma K.
    Wutz, Anton
    Utz, Paul J.
    Chang, Howard Y.
    CELL, 2024, 187 (03) : 733 - 749.e16
  • [3] Xist Ribonucleoproteins Promote Female Sex-biased Autoimmunity
    Dou, Diana
    Zhao, Yanding
    Belk, Julia
    Zhao, Yang
    Casey, Kerriann
    Chen, Derek
    Li, Rui
    Yu, Bingfei
    Srinivasan, Suhas
    Abe, Brian
    Kraft, Katerina
    Hellstroem, Ceke
    Sjoeberg, Ronald
    Chang, Sarah
    Feng, Allan
    Goldman, Daniel
    Shah, Ami
    Petri, Michelle
    Chung, Lorinda
    Fiorentino, David
    Lundberg, Emma
    Wutz, Anton
    Utz, Paul
    Chang, Howard
    ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 25 - 26
  • [4] Immunogenic Xist ribonucleoproteins drive sex-biased autoimmunity
    Jessica McHugh
    Nature Reviews Rheumatology, 2024, 20 : 198 - 198
  • [5] Immunogenic Xist ribonucleoproteins drive sex-biased autoimmunity
    Mchugh, Jessica
    NATURE REVIEWS RHEUMATOLOGY, 2024, 20 (04) : 197 - 197
  • [6] Identification and Analysis of Sex-Biased MicroRNAs in Human Diseases
    Zhong, Bitao
    Cui, Chunmei
    Cui, Qinghua
    GENES, 2023, 14 (09)
  • [7] Long noncoding RNA XIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities
    Li, Jianjian
    Ming, Zhe
    Yang, Liuyi
    Wang, Tingxuan
    Liu, Gaowen
    Ma, Qing
    GENES & DISEASES, 2022, 9 (06) : 1478 - 1492
  • [8] Sex-biased dispersal of human ancestors
    Sugiyama, Yukimaru
    EVOLUTIONARY ANTHROPOLOGY, 2017, 26 (04): : 172 - 180
  • [9] The evolution of sex-biased genes and sex-biased gene expression
    Hans Ellegren
    John Parsch
    Nature Reviews Genetics, 2007, 8 : 689 - 698
  • [10] The evolution of sex-biased genes and sex-biased gene expression
    Ellegren, Hans
    Parsch, John
    NATURE REVIEWS GENETICS, 2007, 8 (09) : 689 - 698
12345