Sperm survival relationship to age-related sperm DNA integrity in infertile men

被引：11
|
作者：
Moskovtsev, S. I. [1 ]
Willis, J. [1 ]
White, J. [1 ]
Mullen, J. B. M. [1 ]
机构：
[1] Mt Sinai Hosp, Dept Pathol & Lab Med, Androl Lab, Toronto, ON M5G 1X5, Canada
来源：
ARCHIVES OF ANDROLOGY | 2007年 / 53卷 / 01期
关键词：
male age; sperm DNA integrity; sperm survival;
D O I：
10.1080/01485010600908330
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
The purpose of our study was to evaluate the effect of age and sperm DNA integrity on sperm survival. Semen samples from fifty six unselected patients undergoing infertility evaluation were assessed in terms of standard semen parameters, DNA integrity, and sperm survival after 6-24 h of incubation. Prolonged incubation of density gradient selected sperm adversely effects sperm survival in older patients and patients with extensive sperm DNA damage. Immediate preparation of such samples prior to use for assisted reproductive technology (ART) may overcome the negative effect of extended incubation.
引用
收藏
页码：29 / 32
页数：4
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