Synthesis of Some New Triphenylphosphanylidenes, Alkylphosphonates, and Heterocycles of Pyrazole Derivatives and Their Antimicrobial Activity

被引：11

作者：

Boulos, Leila S. ^{[1
]}

Ewies, Ewies F. ^{[1
]}

Fahmy, Amin F. M. ^{[2
]}

Mohram, Maysa E. ^{[3
]}

机构：

[1] Natl Res Ctr, Dept Organometall & Organometalloid Chem, Cairo, Egypt

[2] Ain Shams Univ, Dept Chem, Fac Sci, Cairo, Egypt

[3] Natl Res Ctr, Dept Microbial Chem, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2013年 / 188卷 / 06期

关键词：

Pyrazoles; phosphorus ylides; Wittig-Horner reagents; alkyl phosphites; triphenylphosphanylidenes; WITTIG-HORNER REAGENTS; PHOSPHONIUM YLIDES; BEHAVIOR;

D O I：

10.1080/10426507.2012.704104

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reaction of 5(4H)-pyrazolone with phosphorus ylides afforded new triphenylphosphanylidene alkanone derivatives. Moreover, its benzylidene derivative reacted with Wittig-Horner reagents to give the corresponding dialkoxyphosphoryl, alkyl phosphonate, and heterocyclic products. Treatment of pyrazole-4-carbaldehyde with Wittig-Horner reagents and trialkyl phosphites gave the respective alkyl phosphonate adducts. Mechanisms accounting for the formation of the new products are discussed. The biological activity of some of the newly synthesized compounds was also examined.

引用

页码：790 / 803

页数：14

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