Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement

被引：21

作者：

Ge, Xiaowei ^{[2
]}

Low, Min-Yong ^{[2
]}

Zou, Peng ^{[2
]}

Lin, Li ^{[1
]}

Yin, Sharon Oh Sze ^{[2
]}

Bloodworth, Bosco C. ^{[2
]}

Koh, Hwee-Ling ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Sci, Dept Pharm, Singapore 117543, Singapore

[2] Hlth Sci Author, Ctr Analyt Sci, Singapore 169078, Singapore

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2008年 / 48卷 / 04期

关键词：

Health supplement; PDE-5; inhibitor; Adulterant; Liquid chromatography (LC); Mass spectrometry (MS); Nuclear magnetic resonance (NMR);

D O I：

10.1016/j.jpba.2008.08.019

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1-Himidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：1070 / 1075

页数：6

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