A new method for preparation of 3,6-dihydro-2H-1,3-oxazines and explorations of their use in stereoselective synthesis of 1,3-amino alcohol derivatives

被引：14
|
作者：
Cherkauskas, JP
Klos, AM
Borzilleri, RM
Sisko, J
Weinreb, SM
Parvez, M
机构：
[1] PENN STATE UNIV,DEPT CHEM,UNIVERSITY PK,PA 16802
[2] UNIV CALGARY,DEPT CHEM,CALGARY,AB T2N 1N4,CANADA
来源：
TETRAHEDRON | 1996年 / 52卷 / 09期
关键词：
D O I：
10.1016/0040-4020(95)01100-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Condensation of P-hydroxy aldehydes with N-sulfonyl aldimines produces 3,6-dihydro-2H-1,3-oxazines in moderate to excellent yields. The process is stereoselective, with the C-2 and C-6 substituents having a trans relationship in these heterocycles. Some transformations of these oxazines as potential acyclic 1,3-amino alcohol synthons are described.
引用
收藏
页码：3135 / 3152
页数：18
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