Visual event-related potential in mild dementia of the Alzheimer's type

被引:32
|
作者
Saito, H
Yamazaki, M
Matsuoka, M
Matsumoto, K
Numachi, M
Yoshida, S
Ueno, T
Sato, M
机构
[1] Tohoku Univ, Grad Sch Informat Sci, Dept Informat Pathophysiol, Hlth Adm Ctr,Aoba Ku, Sendai, Miyagi 9808576, Japan
[2] Tohoku Univ, Grad Sch Med, Izuminomori Clin, Sendai, Miyagi 980, Japan
[3] Tohoku Univ, Grad Sch Med, Dept Psychiat, Sendai, Miyagi 980, Japan
[4] Tohoku Univ, Fac Educ, Dept Educ Psychol, Sendai, Miyagi 980, Japan
关键词
dementia of the Alzheimer's type; event-related potential; NA potential; P3; potential;
D O I
10.1046/j.1440-1819.2001.00876.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Visual event-related potentials (ERP) and behavioral measures were recorded during a geometrical-figure discrimination task to examine sensory processing in 10 patients with mild dementia of the Alzheimer's type (DAT) and 10 age-matched controls. No difference existed between the groups in P1, N1, and P2 potentials, which reflects the early stage of sensory processing, as well as in NA potential, which reflects pattern recognition. The patients showed reduced amplitude of P3 potential, retarded reaction time, and increased behavioral errors compared to controls. These findings suggest that the patients with mild DAT were intact in early sensory processing including pattern recognition but were selectively compromised in higher-level processing, including integration of information and memory matching, which may influence behavioral deviation.
引用
收藏
页码:365 / 371
页数:7
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