Leonurusoleanolides E-J, Minor Spirocyclic Triterpenoids from Leonurus japonicus Fruits

被引：38
|
作者：
Ye, Miao [1 ,2 ,3 ,4 ]
Xiong, Juan [1 ]
Zhu, Jing-Jing [3 ,4 ]
Hong, Jun-Lin [5 ]
Zhao, Yun [3 ,4 ]
Fan, Hui [3 ,4 ]
Yang, Guo-Xun [1 ]
Xia, Gang [3 ,4 ]
Hu, Jin-Feng [1 ,3 ,4 ]
机构：
[1] Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350122, Peoples R China
[3] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
[4] E China Normal Univ, Inst Adv Interdisciplinary Res, Shanghai 200062, Peoples R China
[5] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 01期
关键词：
CYCLIC NONAPEPTIDES; NORTRITERPENOIDS; HETEROPHYLLUS; LEAVES; CELLS;
D O I：
10.1021/np400838a
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new (leonurusoleanolides E-J, 1-6) and five known (7-11) nortriterpenoids were isolated and characterized from the dried fruits of Leonurus japonicus. They all contain a distinctive 19(18 -> 17)-abeo-28-noroleanane-type spirocylclic skeleton with a trans or a cis acyl substituent at C-3 or C-23. Similar to the previously known leonurusoleanolides A/B (7/8) and C/D (9/10), compounds 1/2 and 3/4 were also found to exist as equilibrium mixtures of trans and cis isomers. The isolated pure compounds and mixtures were evaluated for their cytotoxicity against a small panel of human cancer cell lines (BGC-823 and KE-97 gastric carcinoma, Huh-7 hepatocarcinoma, Jurkat T cell lymphoblasts, and MCF-7 breast adenocarcinoma) using the CellTiter-Glo luminescent cell viability assay method. Among them, (2 alpha,3 beta,17R*,18 beta)-3-O-(trans-caffeoyl)-19(18 -> 17)-abeo-28-norolean-12-ene-2,18,23-triol (leonurusoleanolide J, 6) showed the most potent cytotoxic activity, with IC50 values less than 10 mu M.
引用
收藏
页码：178 / 182
页数：5
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