In-depth study of homogeneity in DBS using two different techniques: results from the EBF DBS-microsampling consortium

被引：1

作者：

Cobb, Zoe ^{[1
]}

de Vries, Ronald ^{[2
]}

Spooner, Neil ^{[3
]}

Williams, Stephen ^{[4
]}

Staelens, Ludovicus ^{[5
]}

Doig, Mira ^{[6
]}

Broadhurst, Rebecca ^{[7
]}

Barfield, Matthew ^{[3
]}

van de Merbel, Nico ^{[8
]}

Schmid, Bernhard ^{[9
]}

Siethoff, Christoph ^{[10
]}

Ortiz, Jordi ^{[11
]}

Verheij, Elwin ^{[12
]}

van Baar, Ben ^{[13
]}

White, Steve ^{[3
]}

Timmerman, Philip ^{[2
]}

机构：

[1] LGC Grp, Quotient Bio Analyt Sci, Fordham CB7 5WW, Cambs, England

[2] Janssen R&D, Beerse, Belgium

[3] GlaxoSmithKline, Ware, Herts, England

[4] Charles River Labs, Wilmington, MA USA

[5] UCB Pharma, Brussels, Belgium

[6] ABS Labs Ltd, Sandy, Beds, England

[7] AstraZeneca, London, England

[8] PRA, Assen, Netherlands

[9] Nuvisan GmbH, Neu Ulm, Germany

[10] Swiss BioQuant, Reinach, Switzerland

[11] Ferrer Int SA, Esplugas de Llobregat, Spain

[12] TNO, NL-3700 AJ Zeist, Netherlands

[13] QPS Netherlands BV, Groningen, Netherlands

来源：

BIOANALYSIS | 2013年 / 5卷 / 17期

关键词：

HEMATOCRIT;

D O I：

10.4155/BIO.13.171

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: At the start of their work, the European Bioanalysis Forum dried blood spots microsampling consortium did not form a dedicated team to investigate the spot homogeneity. However, two teams performed experiments that produced results relating to sample homogeneity. Results: The data, which were produced via two different approaches (a radiolabeled and a nonradiolabeled approach), are highly complementary and demonstrate clear effects on sample inhomogeneity due to the substrate type, compound and hematocrit levels. Conclusion: The results demonstrate that sample inhomogeneity is a significant hurdle to the use of dried blood spots for regulated bioanalysis that should be investigated further in the method establishment phase if the whole spot is not sampled.

引用

页码：2161 / 2169

页数：9

共 12 条

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