Secret(ory) revealed: the long-awaited structures of secretory IgA

被引：8
|
作者：
Herr, Andrew B. [1 ,2 ,3 ]
机构：
[1] Univ Cincinnati, Dept Pediat, Coll Med, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA
来源：
CELL RESEARCH | 2020年 / 30卷 / 07期
关键词：
FC-ALPHA-RI; COMPONENT; INSIGHTS; COMPLEX;
D O I：
10.1038/s41422-020-0351-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Secretory IgA (SIgA) is a specialized form of antibody present at high concentrations in mucosal secretions, where it acts as the first line of defense of the immune system. In a recent paper published in Cell Research, Wang et al. present cryo-EM structures revealing the architecture of SIgA and its interactions with SpsA, a pneumococcal adhesin that piggybacks on SIgA to facilitate gut colonization and host cell invasion by Streptococcus pneumoniae.
引用
收藏
页码：558 / 559
页数：2
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