Carbapenem-resistant Enterobacteriaceae in Pediatric Bloodstream Infections in Rural Southern India

被引：12
|
作者：
Sekar, Ramalingam [1 ]
Mythreyee, Manoharan [1 ]
Srivani, Seetharaman [3 ]
Sivakumaran, Dharmaraj [2 ]
Lallitha, Sivathanu [1 ]
Saranya, Selvam [1 ]
机构：
[1] Tamilnadu Dr MGR Med Univ, Govt Theni Med Coll, Dept Microbiol, Theni, India
[2] Tamilnadu Dr MGR Med Univ, Govt Theni Med Coll, Dept Pediat, Theni, India
[3] Univ Madras, Dept Microbiol, Dr ALM Post Grad Inst Basic Med Sci, Chennai, Tamil Nadu, India
来源：
INDIAN PEDIATRICS | 2017年 / 54卷 / 12期
关键词：
Antimicrobial resistance; Blood culture; Escherichia coli; Klebsiella spp;
D O I：
10.1007/s13312-017-1204-1
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective: To measure the frequency of antimicrobial resistance in pediatric blood culture isolates of Escherichia coli and Klebsiella spp. with focus on carbapenem resistance. Methods: Over a period of three years, pediatric blood culture isolates were tested for antimicrobial susceptibility, including molecular investigations for carbapenem resistance. Results: Amikacin, carbapenems, colistin and tigecycline had an antimicrobial efficacy of >70% (n=140). 7 of the 15 randomly selected isolates were positive for carbapenemase gene; among them, five were New Delhi Metallo beta-lactamase (NDM). Conclusion: There was a high prevalence of Klebsiella spp. in pediatric bacteremia and dissemination of NDM-mediated carbapenem resistance in pediatric wards.
引用
收藏
页码：1021 / 1024
页数：4
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