One-pot, regioselective synthesis of functionalized indole derivatives: a three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone

A metal free, one-pot tandem synthetic routes for functionalized indole derivatives has been established. An efficient three-component reaction was designed with incorporation of Knoevenagel condensation followed by inter-, and intramolecular nucleophilic addition reaction in one-pot under mild condition. The structural diversities of the synthesized compounds have been confirmed spectroscopically, by IR, H-1- and C-13 NMR, and elemental analyses which agree with the proposed structures. [GRAPHICS] .