One-pot, regioselective synthesis of functionalized indole derivatives: a three-component domino reaction of arylamine, arylglyoxal, and 4-hydroxycoumarin or 4-hydroxy-6-methyl-2-pyrone

被引：4
|
作者：
Mehrabi, Hossein [1 ]
Dastouri, Fatemeh [1 ]
Asadi, Sara [1 ]
Alizadeh-Bami, Farzaneh [1 ]
Ranjbar-Karimi, Reza [1 ]
机构：
[1] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan 77176, Iran
来源：
ARKIVOC | 2020年
关键词：
Arylamine; Arylglyoxal; 4-Hydroxycoumarin; 4-Hydroxy-6-methyl-2-pyrone; Functionalized indole derivatives; ANTIBACTERIAL; ANTIOXIDANT; ANTICANCER; EFFICIENT; ALKALOIDS;
D O I：
10.24820/ark.5550190.p011.151
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal free, one-pot tandem synthetic routes for functionalized indole derivatives has been established. An efficient three-component reaction was designed with incorporation of Knoevenagel condensation followed by inter-, and intramolecular nucleophilic addition reaction in one-pot under mild condition. The structural diversities of the synthesized compounds have been confirmed spectroscopically, by IR, H-1- and C-13 NMR, and elemental analyses which agree with the proposed structures. [GRAPHICS] .
引用
收藏
页码：114 / 125
页数：12
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