Zirconium Oxide Nanoparticles Modified Carbon Paste Electrode for Simultaneous Voltammetric Determination of Mebendazole and Levamisole Hydrochloride in Pharmaceutical Formulation and Human Plasma

A new, simple and highly sensitive electrochemical method based on zirconium oxide nanoparticles modified carbon paste electrode (2 % ZrO2/CPE) was used for simultaneous determination of anthelmintics drugs Mebendazole (MB) and Levamisole HCl (LV) in drug substance, dosage form and human plasma. Differential pulse (DPV) and square wave (SWV) voltammetric analysis were applied in Britton Robinson buffer (pH 6; 0.04 M) after optimization of different analytical parameters. The studied drugs were measured simultaneously at very low concentration of analytes resulting in two well-separated peaks. The detection limits were found to be 0.01 and 0.62 mu M for MB and LV, respectively, using DPV and 0.01 and 0.42 mu M for MB and LV, respectively using SWV.