Cardioprotective effect of N-(benzo[d]oxazol-2-yl)-2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinecarboxamide against doxorubicin induced cardiotoxicity in rats

被引：1
|
作者：
Reddy, A. Rama Narsimha [1 ]
Nagaraju, J. [1 ]
Rajyalaksmi, G. [2 ]
Sarangapani, M. [2 ]
机构：
[1] Vaageswari Coll Pharm, Dept Pharmacol, Karimnagar 505481, Andhra Pradesh, India
[2] Kakatiya Univ, Dept Pharmaceut Chem, Univ Coll Pharmaceut Sci, Waranagal 506001, Andhra Pradesh, India
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2012年 / 94卷 / 10期
关键词：
cardiotoxicity; N-(benzo[d]oxazol-2-yl)-2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinecarboxamide; cardioprotective; doxorubicin; LDH; CK-MB; AST; TG;
D O I：
10.1080/02772248.2012.741335
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The present study was aimed to evaluate the cardioprotective activity of N-(benzo[d]oxazol-2-yl)-2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinecarboxamide (coded as ARL) in rats. Doxorubicin (DOX) (15 mg kg(-1), i.p, single dose) was used to induce cardiotoxicity in rats. Four groups of female Wistar albino rats were used. Group 1 was used as control (0.5% CMC, oral); the other groups were treated with DOX (single i.p. dosage of 15 mg kg(-1)) or DOX plus compound ARL (50 or 100mg kg(-1) day(-1), p.o.), respectively. Animals were treated with ARL or CMC for 7 days. On 6th day, a single dose of DOX was administered to rats. Blood was collected on 7th day. Evaluation of cardioprotective activity was estimated using biochemical parameters including plasma aspartate aminotransferase, creatine kinase (CK-MB), lactate dehydrogenase (LDH), and triglycerides (TG) levels. Pretreatment with compound ARL significantly reduced the elevated levels of cardiotoxic biomarkers in plasma. DOX-induced depletion of glutathione levels in blood was significantly alleviated by pretreatment with compound ARL.
引用
收藏
页码：2012 / 2018
页数：7
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