Chemoenzymatic synthesis of deoxyfluoroinositols: 5-Deoxy-5-fluoro-myo-inositol and 3-deoxy-3-fluoro-L-chiro-inositol

被引：0

作者：

Nguyen, BV ^{[1
]}

York, C ^{[1
]}

Hudlicky, T ^{[1
]}

机构：

[1] UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611

来源：

TETRAHEDRON | 1997年 / 53卷 / 26期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two deoxyfluoroinositols were synthesized from bromocyclohexadiene cis-diol obtained by microbial oxidation of bromobenzene with P. putida (39D). The selective introduction of fluorine was accomplished by opening of the epoxide with tetrabutylphosphoniumfluoride dihydrofluoride (TBPF-DF). The synthesis of 5-deoxy-5-fluoro-myo-inositol (1) and 3-deoxy-3-fluoro-L-chiro-inositol (2) are described in detail. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：8807 / 8814

页数：8

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