Chemoenzymatic synthesis of deoxyfluoroinositols: 5-Deoxy-5-fluoro-myo-inositol and 3-deoxy-3-fluoro-L-chiro-inositol

被引：0
|
作者：
Nguyen, BV [1 ]
York, C [1 ]
Hudlicky, T [1 ]
机构：
[1] UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611
来源：
TETRAHEDRON | 1997年 / 53卷 / 26期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two deoxyfluoroinositols were synthesized from bromocyclohexadiene cis-diol obtained by microbial oxidation of bromobenzene with P. putida (39D). The selective introduction of fluorine was accomplished by opening of the epoxide with tetrabutylphosphoniumfluoride dihydrofluoride (TBPF-DF). The synthesis of 5-deoxy-5-fluoro-myo-inositol (1) and 3-deoxy-3-fluoro-L-chiro-inositol (2) are described in detail. (C) 1997 Published by Elsevier Science Ltd.
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页码：8807 / 8814
页数：8
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