Association studies of 5-HT2A and 5-HT2C serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients

被引：0

作者：

Dmitrzak-Weglarz, M

Rybakowski, JK

Suwalska, A

Slopien, A

Czerski, PM

Leszczynska-Rodziewicz, A

Hauser, J

机构：

[1] Poznan Univ Med Sci, Lab Psychiat Genet, Dept Psychiat, PL-60572 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Adult Psychiat, PL-60572 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Child & Adolescent Psychiat, PL-60572 Poznan, Poland

来源：

PHARMACOLOGICAL REPORTS | 2005年 / 57卷 / 06期

关键词：

lithium prophylaxis; bipolar disorder; 5-HT2A; serotonin receptor 2A gene; 5-HT2C; serotonin receptor 2C gene; pharmacogenetics;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lithium is one of the most commonly used drugs in the prophylaxis and treatment of bipolar disorder. The mechanisms of mood stabilization by lithium incorporate its effect. on serotonergic neurotransmission.' This paper investigates a relationship between response to lithium prophylaxis and polymorphisms in two genes: T102C of 5-HT2A receptor and G68C (Cys23Ser) of 5-HT2C serotonin receptor gene. Genotypes were estimated in 92 bipolar patients (39 males and 53 females) who have been taking lithium for at least 5 years. The patients were classified as excellent responders, partial responders and non-responders to lithium. The obtained results suggest that these polymorphisms may not be related to the degree of prophylactic lithium response.

引用

页码：761 / 765

页数：5

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