Nickel-catalyzed three-component [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes - Selective synthesis of multisubstituted cycloheptadienes

被引：109

作者：

Komagawa, S ^{[1
]}

Saito, S ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Chem, Tokyo 1628601, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期

关键词：

alkynes; cycloaddition; cycloheptadienes; nickel; synthetic methods;

D O I：

10.1002/anie.200504050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Ménage à trois: Seven-membered carbocycles are formed by the three-component [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and two different alkynes in the presence of a Ni 0/PPh3 catalyst (see scheme). In this one-pot reaction, a highly chemo- and regioselective coupling proceeds, and the cycloheptadiene derivatives are isolated as single isomers. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2446 / 2449

页数：4

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