Evaluation of in vitro antioxidant and anticancer activity of Alpinia purpurata

被引：9

作者：

Raj, Chinthamony Arul ^{[1
]}

Ragavendran, Paramasivam ^{[1
]}

Sophia, Dominic ^{[1
]}

Rathi, Muthaiyan Ahalliya ^{[1
]}

Gopalakrishnan, Velliyur Kanniappan ^{[1
]}

机构：

[1] Karpagatn Univ, Dept Biochem, Coimbatore 641021, Tamil Nadu, India

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2012年 / 10卷 / 04期

关键词：

Alpinia purpurata; Ethylacetate; Antioxidants; Anticancer; OAW42; INHIBITION; EXTRACTS; ASSAY;

D O I：

10.3724/SP.J.1009.2012.00263

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

AIM: Ethylacetate extract of Alpinia purpurata was evaluated for its potential in vitro antioxidant and anticancer activity. METHODS: The antioxidant activity was evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method, hydroxyl radical activity, superoxide radical scavenging activity, nitric oxide radical scavenging activity, hydrogen peroxide radical scavenging activity and reducing power activity. The viability of OAW42 cells was evaluated by MTT assay. RESULTS: A. purpurata exhibited potential antioxidant activity with a concentration-dependent manner. The extract showed potential anticancer activity at the 48th hour with IC50 of 130.20 mu g.mL(-1) and exhibited a dose-dependent decrease in cell count for all the concentrations tested. CONCLUSION: The results suggested that long term consumption of A. purpurata exhibited antioxidant and anticancer activity and could be further exploited for their anticancer properties.

引用

页码：263 / 268

页数：6

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