Lessons learnt from structural studies of the oestrogen receptor

被引：95

作者：

Pike, ACW

机构：

[1] Structural Biology Laboratory, Chemistry Department, University of York

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2006年 / 20卷 / 01期

基金：

英国惠康基金;

关键词：

receptor agonist; antagonist; protein structure; selective oestrogen receptor modulator; SERM; activation function 2; ligand-binding domain;

D O I：

10.1016/j.beem.2005.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the last 10 years, structural studies of the ligand-binding domains of nuclear hormone receptors have provided a wealth of information on the nature of ligand-binding and its role in receptor activation. This review examines the insights that studies on oestrogen receptor subtypes ER alpha. and ER beta have provided in terms of (1) basis of receptor activation; (2) recruitment of coregulators; (3) hormone recognition; and (4) subtype-selective ligands. It also highlights the implications for the binding of endocrine disruptors.

引用

页码：1 / 14

页数：14

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