Immune checkpoint alterations and their blockade in COVID-19 patients

被引：5
|
作者：
Tan, Jiaxiong [1 ]
Li, Yangqiu [2 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Dept Hematol, Guangzhou, Peoples R China
[2] Jinan Univ, Sch Med, Inst Hematol, Key Lab Regenerat Med,Minist Educ, Guangzhou, Peoples R China
来源：
BLOOD SCIENCE | 2022年 / 4卷 / 04期
关键词：
T-CELLS; PD-1; LYMPHOCYTES; SARS-COV-2; SIGNATURE;
D O I：
10.1097/BS9.0000000000000132
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronavirus disease 2019 (COVID-19) is a highly contagious disease that seriously affects people's lives. Immune dysfunction, which is characterized by abnormal expression of multiple immune checkpoint proteins (ICs) on immune cells, is associated with progression and poor prognosis for tumors and chronic infections. Immunotherapy targeting ICs has been well established in modulating immune function and improving clinical outcome for solid tumors and hematological malignancies. The role of ICs in different populations or COVID-19 stages and the impact of IC blockade remains unclear. In this review, we summarized current studies of alterations in ICs in COVID-19 to better understand immune changes and provide strategies for treating COVID-19 patients, particularly those with cancer.
引用
收藏
页码：192 / 198
页数：7
相关论文
共 50 条
  • [41] Proteasomal processing alterations as a novel mechanism of immune escape in NSCLC stratifies patients for response to immune checkpoint blockade
    Wessolly, Michael
    Wiesweg, Marcel
    Borchert, Sabrina
    Beckert, Hendrik
    Stephan-Falkenau, Susann
    Mairinger, Elena
    Kollmeier, Jens
    Aigner, Clemens
    Taube, Christian
    Wohlschlaeger, Jeremias
    Bauer, Thorsten
    Mairinger, Thomas
    Schmid, Kurt Werner
    Schuler, Martin
    Reis, Henning
    Mairinger, Fabian Dominik
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 3) : 157 - 157
  • [42] COVID-19 mRNA vaccines and immune-related adverse events in cancer patients treated with immune checkpoint inhibitors
    Chen, Yu-Wei
    Tucker, Matthew D.
    Beckermann, Kathryn E.
    Iams, Wade T.
    Rini, Brian I.
    Johnson, Douglas B.
    EUROPEAN JOURNAL OF CANCER, 2021, 155 : 291 - 293
  • [43] The impact of COVID-19 infection on immune-related adverse events in patients with cancer receiving immune checkpoint inhibitors
    Guo, Mengni
    Liu, Jieying
    Ahmed, Zohaib
    Yu, James
    Miao, Ruoyu
    Guan, Jian
    Pour, Mohammad Ali Esmaeil
    Khayyat, Azadeh
    Grove, Angela
    Manoucheri, Manoucher
    Socinski, Mark A.
    Mekhail, Tarek
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [44] Oral Fungal Alterations in Patients with COVID-19 and Recovered Patients
    Hu, Xiaobo
    Wang, Haiyu
    Yu, Bo
    Yu, Jia
    Lu, Haifeng
    Sun, Junyi
    Sun, Ying
    Zou, Yawen
    Luo, Hong
    Zeng, Zhaohai
    Liu, Shanshuo
    Jiang, Yan
    Wu, Zhongwen
    Ren, Zhigang
    ADVANCED SCIENCE, 2023, 10 (19)
  • [45] Alterations in the immune system persist after one year of convalescence in severe COVID-19 patients
    Abarca-Zabalia, Judith
    Gonzalez-Jimenez, Adela
    Calle-Rubio, Myriam
    Lopez-Pastor, Andrea R.
    Farina, Tomas
    Ramos-Acosta, Carlos
    Anguita, Eduardo
    Urcelay, Elena
    Espino-Paisan, Laura
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [46] Immune Responses in Patients with COVID-19: An Overview
    Kamat, Deepak
    Kamat, Aarti
    Mathur, Ambika
    PEDIATRIC ANNALS, 2021, 50 (05): : E222 - E226
  • [47] Overactive Immune Response in Patients with COVID-19
    不详
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2022, 147 (04)
  • [48] COVID-19 vaccination in patients with immune thrombocytopenia
    Visser, Chantal
    Swinkels, Maurice
    van Werkhoven, Erik D.
    Croles, F. Nanne
    Noordzij-Nooteboom, Heike S.
    Eefting, Matthijs
    Last-Koopmans, Suzanne M.
    Idink, Cecile
    Westerweel, Peter E.
    Santbergen, Bart
    Jobse, Pieter A.
    Baboe, Fazil
    Te Boekhorst, Peter A. W.
    Leebeek, Frank W. G.
    Levin, Mark-David
    Kruip, Marieke J. H. A.
    Jansen, A. J. Gerard
    BLOOD ADVANCES, 2022, 6 (06) : 1637 - 1644
  • [49] Peripheral lymphocyte subset alterations in COVID-19 patients
    Chan, Stephrene S. W.
    Christopher, Dheepa
    Tan, Guat B.
    Chong, Vanessa C. L.
    Fan, Bingwen E.
    Lin, Clement Y.
    Ong, Kiat H.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2020, 42 (05) : E199 - E203
  • [50] Increased myositis and possible myocarditis in melanoma patients treated with immune checkpoint inhibitors in the COVID-19 era
    Gradone, Allison L.
    Ma, Vincent T.
    Vasbinder, Alexi
    Fecher, Leslie A.
    Yentz, Sarah
    Hayek, Salim S.
    Lao, Christopher D.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (12)
12345