Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

被引：39
|
作者：
Jin, Wook [1 ]
机构：
[1] Gachon Univ, Sch Med, Dept Biochem, Lab Mol Dis & Cell Regulat, Incheon 406840, South Korea
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
PARK7 (DJ-1); therapeutic target; apoptosis; redox sensor; chemoresistance; FAMILIAL PARKINSONS-DISEASE; CELL LUNG-CARCINOMA; ANDROGEN RECEPTOR; INDUCED APOPTOSIS; HEPATOCELLULAR-CARCINOMA; PROTEOMIC ANALYSIS; GASTRIC-CANCER; UP-REGULATION; DIFFERENTIAL-DIAGNOSIS; POSITIVE CORRELATION;
D O I：
10.3390/jcm9051256
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and Huntington disease. PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy. Additionally, secreted PARK7 has been identified as a high-risk factor for the pathogenesis and survival of various cancers. This review summarizes the current understanding of the correlation between the expression of PARK7 and tumor progression.
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页数：18
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