Synthesis and Biological Evaluation of (E)-N′-Benzylidene-7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazides as Antioxidant, Anti-inflammatory and Analgesic agents

被引：19
|
作者：
Katikireddy, Ramamurthy [2 ,3 ]
Kakkerla, Ramu [1 ]
Krishna, M. P. S. Murali [4 ]
Durgaiah, Gandamalla [5 ]
Reddy, Y. N. [5 ]
Satyanarayana, Mavurapu [6 ]
机构：
[1] Satavahana Univ, Dept Chem, Karimnagar 505001, Telangana, India
[2] JNTU, Dept Chem, Kakinada 533003, Andhra Pradesh, India
[3] Enantilabs Pvt Ltd, JN Pharmac, Visakapatnam 531019, Andhra Pradesh, India
[4] Andhra Polytech Coll, Dept Chem, Kakinada 533003, Andhra Pradesh, India
[5] Kakatiya Univ, Dept Pharmacol & Toxicol, Warangal 506009, Telangana, India
[6] Telangana Univ, Dept Pharmaceut Chem, Nizamabad 503322, Telangana, India
来源：
HETEROCYCLIC COMMUNICATIONS | 2019年 / 25卷 / 01期
关键词：
Benzimidazolyl hydrazones; antioxidant activity; anti-inflammatory activity; analgesic activity and acid hydrazide; VIRUS NS5B POLYMERASE; NONNUCLEOSIDE INHIBITORS; DESIGN; HYDRAZONES; DISCOVERY; TEMPERATURE; EFFICIENT; SERIES; SAR;
D O I：
10.1515/hc-2019-0009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(E)-N'-Benzylidene-7-methyl-2-propyl-1H-benzo [d]imidazole-5-carbohydrazides (5a-r) have been synthesized from 7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazide (3) by condensing with different aromatic aldehydes (4a-r). Title compounds (5a-r) were evaluated for in vitro antioxidant activity and based on their potential for antioxidant property, selected compounds 5d and 5m-p were screened for in vivo anti-inflammatory and analgesic activity. The results indicate that the compound 5o and 5p are effective against anti-inflammatory and analgesic activity. The biological data was further supported by molecular docking studies, which revealed the binding pattern and the affinity of the molecules in the active site of COX-2.
引用
收藏
页码：27 / 38
页数：33
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