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- [21] Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388):: A potent, selective, and orally active transforming growth factor-β type I receptor inhibitorJOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (07) : 2210 - 2221Gellibert, Fde Gouville, ACWoolven, JMathews, NNguyen, VLBertho-Ruault, CPatikis, AGrygielko, ETLaping, NJHuet, S
- [22] Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V1A receptorJOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) : 2589 - 2598Kakefuda, ASuzuki, TTobe, TTsukada, JTahara, ASakamoto, STsukamoto, S
- [23] N-[3-(2-dimethylaminoethyl)-2-methyl-1H-indol-5-yl]-4-fluorobenzamide:: A potent, selective, and orally active 5-HT1F receptor agonist potentially useful for migraine therapyJOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (24) : 4031 - 4034Xu, YCJohnson, KWPhebus, LACohen, MNelson, DLSchenck, KWalker, CDFritz, JEKaldor, SWLeTourneau, MEMurff, REZgombick, JMCalligaro, DOAudia, JESchaus, JM
- [24] SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-{[(6-methoxy-2-naphthyl)sulfonyl]amino}propanoyl)amino]-3-(4-{[2R,6S)-2,6-dimethylpiperidinyl]methyl}phenyl)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor:: Biochemical and pharmacological characterizationJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 309 (02): : 661 - 669Gougat, JFerrari, BSarran, LPlanchenault, CPoncelet, MMaruani, JAlonso, RCudennec, ACroci, TGuagnini, FUrban-Szabo, KMartinolle, JPSoubrié, PFinance, OLe Fur, G
- [25] Discovery of a potent, selective, and orally bioavailable c-Met inhibitor:: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458)JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (13) : 3688 - 3691Liu, LongbinSiegmund, AaronXi, NingKaplan-Lefko, PaulaRex, KarenCheti, AprilLin, JasmineMoriguchi, JodiBerry, LorenHuang, LiyueTeffera, YohannesYang, YajingZhang, YihongBellon, Steven F.Lee, MatthewShimanovich, RomanBak, AnnetteDominguez, CeliaNorman, Mark H.Harmange, Jean-ChristopheDussault, IsabelleKimt, Tae-Seong
- [26] 5-fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985):: An orally active arginine vasopressin antagonist with selectivity for V2 receptorsJOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (14) : 2442 - 2444Albright, JDReich, MFDelos Santos, EGDusza, JPSum, FWVenkatesan, AMCoupet, JChan, PSRu, XMazandarani, HBailey, T
- [27] Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid LeukemiaJOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (05) : 1984 - 2004Liang, XiaofeiLiu, XiaochuanWang, BeileiZou, FengmingWang, AoliQi, ShuanChen, ChengZhao, ZhengWang, WenchaoQi, ZipingLv, FengchaoHu, ZhenquanWang, LiZhang, ShanchunLiu, QingsongLiu, Jing
- [28] Discovery of N-{(1S,2S)-2-(3-Cyanophenyl)-3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical useJOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (15) : 3427 - 3430Liu, PingLin, Linus S.Hamill, Terence G.Jewell, James P.Lanza, Thomas J., Jr.Gibson, Raymond E.Krause, Stephen M.Ryan, ChristineEng, WaisiSanabria, SandraTong, XinchunWang, JunyingLevorse, Dorothy A.Owens, Karen A.Fong, Tung M.Shen, Chun-PynLao, JulieKumar, SanjeevYin, WenjiPayack, Joseph F.Springfield, Shawn A.Hargreaves, RichardBurns, H. DonaldGoulet, Mark T.Hagmann, William K.
- [29] Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and AntagonistJOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (20) : 8128 - 8140De Savi, ChrisBradbury, Robert H.Rabow, Alfred A.Norman, Richard A.de Almeida, CamilaAndrews, David M.Ballard, PeterButtar, DavidCallis, Rowena J.Currie, Gordon S.Curwen, Jon O.Davies, Chris D.Donald, Craig S.Feron, Lyman J. L.Gingell, HelenGlossop, Steven C.Hayter, Barry R.Hussain, SyeedKaroutchi, GalithLamont, Scott G.MacFaul, PhilipMoss, Thomas A.Pearson, Stuart E.Tonge, MichaelWalker, Graeme E.Weir, Hazel M.Wilson, Zena
- [30] Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonistJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (03): : 1122 - 1130Serradeil-Le Gal, CWagnon, JSimiand, JGriebel, GLacour, CGuillon, GBarberis, CBrossard, GSoubrié, PNisato, DPascal, MPruss, RScatton, BMaffrand, JPLe Fur, G