Paramyosin: A candidate vaccine antigen against Schistosoma japonicum

被引：61
|
作者：
Ramirez, BL
Kurtis, JD
Wiest, PM
Arias, P
Aligui, F
Acosta, L
Peters, P
Olds, GR
机构：
[1] RES INST TROP MED,MANILA,PHILIPPINES
[2] BROWN UNIV,INT HLTH INST,PROVIDENCE,RI 02912
来源：
PARASITE IMMUNOLOGY | 1996年 / 18卷 / 01期
关键词：
Schistosoma japonicum; trematode; paramyosin; immunity;
D O I：
10.1046/j.1365-3024.1996.d01-4.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Paramyosin, a 97 kDa myofibrillar protein, is a candidate vaccine antigen for prevention of infection with the human parasite Schistosoma mansoni. To determine if paramyosin would also induce protection against Schistosoma japonicum, paramyosin was biochemically purified from S. japonicum adult worms. SDS-PAGE demonstrated a single protein with a molecular weight of 97 kDa. In four separate experiments, vaccination of mice with S. japonicum paramyosin without adjuvant induced significant resistance (62%-86%, P < 0.001) against cercarial challenge as compared to controls. These data suggest that S. japonicum paramyosin may represent a candidate vaccine for immunization against schistosomiasis japonica.
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收藏
页码：49 / 52
页数：4
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