Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?

被引：7
|
作者：
Bortolato, Andrea [1 ]
Cozza, Giorgio [1 ]
Moro, Stefano [1 ]
机构：
[1] Univ Padua, Dipartimento Sci Farmaceut, MMS, I-35131 Padua, Italy
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 07期
关键词：
Protein kinase CK2; casein kinase 2; anticancer drugs; drug discovery;
D O I：
10.2174/187152008785914761
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Protein kinase CK2 is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. A number of structurally unrelated CK2 inhibitors, tested on a variety of cells derived from tumours, including lymphomas, leukaemias, multiple myeloma and prostate carcinoma, display a proapoptotic effect which is roughly proportional to their in vitro inhibitory potency. In the present review we summarize the most recent discovery of potent and selective CK2 inhibitors and their prospective as future anticancer agents.
引用
收藏
页码：798 / 806
页数：9
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