Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic O,O-Acetals

被引：19

作者：

Xiong, Wenfang ^{[1
]}

Yan, Donghao ^{[1
]}

Qi, Chaorong ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; CARBON-DIOXIDE; PROPARGYLIC ALCOHOLS; ASYMMETRIC ADDITION; EFFICIENT SYNTHESIS; CO2; INCORPORATION; ATMOSPHERIC CO2; MULTICOMPONENT REACTIONS; N-TOSYLHYDRAZONES; METAL-FREE;

D O I：

10.1021/acs.orglett.7b03808

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed four-component cascade reaction of carbon dioxide, amines, allenyl ethers, and aryl iodides has been developed for the first time. The novel reaction allows simultaneous construction of three different new bonds (C-N, C-O, and C-C) in a single step, affording an efficient method for the synthesis of a variety of highly functionalized acyclic O,O-acetals. Excellent chemo- and regioselectivity, wide substrate scope, and good functional group tolerance are features of the method.

引用

页码：672 / 675

页数：4

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