The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

被引：65

作者：

Grau-Perez, Maria ^{[1
,2
]}

Kuo, Chin-Chi ^{[1
,3
,4
,5
,6
,7
]}

Spratlen, Miranda ^{[1
]}

Thayer, Kristina A. ^{[8
]}

Mendez, Michelle A. ^{[9
]}

Hamman, Richard F. ^{[10
]}

Dabelea, Dana ^{[10
]}

Adgate, John L. ^{[11
]}

Knowler, William C. ^{[12
]}

Bell, Ronny A. ^{[13
]}

Miller, Frederick W. ^{[14
]}

Liese, Angela D. ^{[15
]}

Zhang, Chongben ^{[9
]}

Douillet, Christelle ^{[9
]}

Drobna, Zuzana ^{[9
,16
]}

Mayer-Davis, Elizabeth J. ^{[9
,17
]}

Styblo, Miroslav ^{[9
]}

Navas-Acien, Ana ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA

[2] Columbia Univ, Dept Environm Hlth Sci, Mailman Sch Publ Hlth, New York, NY 10027 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA

[5] China Med Univ Hosp, Kidney Inst, Taichung, Taiwan

[6] China Med Univ Hosp, Div Nephrol, Dept Internal Med, Taichung, Taiwan

[7] China Med Univ, Coll Med, Taichung, Taiwan

[8] NIEHS, Div Natl Toxicol Program, Dept Hlth & Human Serv, NIH, POB 12233, Res Triangle Pk, NC 27709 USA

[9] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA

[10] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA

[11] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Environm & Occupat Hlth, Aurora, CO USA

[12] NIDDK, Diabet Epidemiol & Clin Res Sect, Phoenix, AZ USA

[13] Wake Forest Sch Med, Winston Salem, NC USA

[14] NIEHS, NIH, Bethesda, MD USA

[15] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA

[16] North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA

[17] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Med, Chapel Hill, NC USA

来源：

DIABETES CARE | 2017年 / 40卷 / 01期

关键词：

METHYLATION CAPACITY; TRIVALENT ARSENICALS; FOLIC-ACID; COHORT; PREVALENCE; DISEASE; WATER; RISK;

D O I：

10.2337/dc16-0810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes. RESEARCH DESIGN AND METHODS Six hundred eighty-eight participants <22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated. Arsenic species (inorganic arsenic [iAs], monomethylated arsenic [MMA], dimethylated arsenic [DMA]), and one-carbon metabolism biomarkers (folate and vitamin B12) were measured in plasma. We used the sum of iAs, MMA, and DMA (Sigma As) and the individual species as biomarkers of arsenic concentrations and the relative proportions of the species over their sum (iAs%, MMA%, DMA%) as biomarkers of arsenic metabolism. RESULTS Median Sigma As, iAs%, MMA%, and DMA% were 83.1 ng/L, 63.4%, 10.3%, and 25.2%, respectively. Sigma As was not associated with either type of diabetes. The fully adjusted odds ratios (95% CI), rescaled to compare a difference in levels corresponding to the interquartile range of iAs%, MMA%, and DMA%, were 0.68 (0.50-0.91), 1.33 (1.02-1.74), and 1.28 (1.01-1.63), respectively, for type 1 diabetes and 0.82 (0.48-1.39), 1.09 (0.65-1.82), and 1.17 (0.77-1.77), respectively, for type 2 diabetes. In interaction analysis, the odds ratio of type 1 diabetes by MMA% was 1.80 (1.25-2.58) and 0.98 (0.70-1.38) for participants with plasma folate levels above and below the median (P for interaction = 0.02), respectively. CONCLUSIONS Low iAs% versus high MMA% and DMA% was associated with a higher odds of type 1 diabetes, with a potential interaction by folate levels. These data support further research on the role of arsenic metabolismin type 1 diabetes, including the interplay with one-carbon metabolism biomarkers.

引用

页码：46 / 53

页数：8

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