Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

被引：359
|
作者：
Kunkel, Gregory T. [1 ]
Maceyka, Michael [1 ]
Milstien, Sheldon [1 ]
Spiegel, Sarah [1 ]
机构：
[1] Virginia Commonwealth Univ, Sch Med, Massey Canc Ctr, Dept Biochem & Mol Biol, Richmond, VA 23298 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 09期
基金：
美国国家卫生研究院;
关键词：
SPHINGOSINE KINASE 1; SIGNAL-REGULATED KINASE-1/2; PERSISTENT STAT3 ACTIVATION; 1-PHOSPHATE RECEPTORS; TRANSPORTER SPNS2; S1P(1) ANTAGONIST; LYMPHOCYTE TRAFFICKING; ENDOTHELIAL-CELLS; FTY720; INHIBITION;
D O I：
10.1038/nrd4099
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted - for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.
引用
收藏
页码：688 / 702
页数：15
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