A functional and proteomics analysis of AKT1(E17K) in human mammary epithelial cells of luminal and myoepithelial cells of origin

被引:0
|
作者
Salhia, Bodour [1 ]
DuQuette, Rachelle A. [1 ]
Van Cott, Courtney [1 ]
Tegler, Tony [1 ]
Polpitiya, Ashoka [1 ]
Petritis, Konstantinos [1 ]
Carpten, John [1 ]
机构
[1] TGen, Phoenix, AZ USA
关键词
D O I
10.1158/1538-7445.AM2011-1060
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1060
引用
收藏
页数:1
相关论文
共 50 条
  • [41] De novo induction of lineage plasticity from human prostate luminal epithelial cells by activated AKT1 and c-Myc
    Oh-Joon Kwon
    Li Zhang
    Deyong Jia
    Zhicheng Zhou
    Zhouyihan Li
    Michael Haffner
    John K. Lee
    Lawrence True
    Colm Morrissey
    Li Xin
    Oncogene, 2020, 39 : 7142 - 7151
  • [42] De novo induction of lineage plasticity from human prostate luminal epithelial cells by activated AKT1 and c-Myc
    Kwon, Oh-Joon
    Zhang, Li
    Jia, Deyong
    Zhou, Zhicheng
    Li, Zhouyihan
    Haffner, Michael
    Lee, John K.
    True, Lawrence
    Morrissey, Colm
    Xin, Li
    ONCOGENE, 2020, 39 (48) : 7142 - 7151
  • [43] AKT1 (E17K) mutation: coexistence with oncogenic alterations, prevalence, and correlation to clinical parameter in a large series of breast cancer patients
    Rudolph, Marion
    Anzeneder, Tobias
    Ocker, Matthias
    Lagkadinou, Eleni
    Politz, Oliver
    Michels, Martin
    Schulz, Anke
    Beckmann, Georg
    Teufel, Michael
    Seidel, Henrik
    Soong, Richie
    Bodenmueller, Heinz
    Ohlms, Ulla
    Asadullah, Khusru
    Reischl, Joachim
    CANCER RESEARCH, 2014, 74 (19)
  • [44] AKT1 E17K AND NF2 MUTATIONS DOMINATE SPINAL MENINGIOMAS WHO GRADE 1 AND PRESENT DISTINCT TUMOR FEATURES
    Hua, Lingyang
    Alkhatib, Majd
    Meinhardt, Matthias
    Cahill, Daniel
    Brastianos, Priscilla
    Clark, Victoria
    Shankar, Ganesh
    Wakimoto, Hiroaki
    Schackert, Gabriele
    Juratli, Tareq
    NEURO-ONCOLOGY, 2022, 24 : 253 - 253
  • [45] Discovery of ALTA-2618, the first allosteric, mutant-selective targeted therapy for AKT1 E17K driven cancers
    Murphy, Eric A.
    Bartberger, Michael D.
    Ibanez, Maureen
    Smith, Troy T.
    Alvarez, Nicole
    Timple, Noel
    Zhu, Xuefeng
    Fan, Kevin
    Yu, Kevin
    CANCER RESEARCH, 2024, 84 (07)
  • [46] The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 significantly promotes v-ABL-mediated cellular transformation
    Chen, Jilong
    Li, Zhiguo
    Qiao, Zhenzhen
    Wang, Zixu
    Chen, Yaoxing
    CANCER RESEARCH, 2009, 69
  • [47] Ciliated muconodular papillary tumor-like neoplasm of the nasal cavity with concurrent BRAF V600E and AKT1 E17K mutations
    Lee, Wan-Ting
    Lin, Pin-Yu
    Lee, Yi-Hsuan
    Hsieh, Min-Shu
    PATHOLOGY INTERNATIONAL, 2022, 72 (04) : 264 - 266
  • [48] Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas
    Eom, Hyeon Seok
    Kim, Min Sung
    Hur, Soo Young
    Yoo, Nam Jin
    Lee, Sug Hyung
    ACTA ONCOLOGICA, 2009, 48 (07) : 1084 - 1085
  • [49] Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells
    G Guo
    X Qiu
    S Wang
    Y Chen
    P B Rothman
    Z Wang
    Y Chen
    G Wang
    J-L Chen
    Oncogene, 2010, 29 : 3845 - 3853
  • [50] Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells
    Guo, G.
    Qiu, X.
    Wang, S.
    Chen, Y.
    Rothman, P. B.
    Wang, Z.
    Chen, Y.
    Wang, G.
    Chen, J-L
    ONCOGENE, 2010, 29 (26) : 3845 - 3853