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- [24] 1α,25(OH)2D3 increases AP-1 DNA binding activity via the annexin II membrane receptor by a PI3-kinase/Ras/MEK/ERK1/2 and JNK1 dependent mechanism:: In vitro and in vivo regulation of AP-1 binding activity by 1α,25(OH)2D3 and calcipotriol JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (03) : 754 - 754