Pfizer's dual-acting β2 agonists/muscarinic M3 antagonists

被引：0
|
作者：
Norman, Peter [1 ]
机构：
[1] Norman Consulting, Burnham SL1 8JW, Bucks, England
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2008年 / 18卷 / 09期
关键词：
asthma; beta(2) agonist; bronchodilator; COPD; M3; antagonist; MABA; muscarinic antagonist;
D O I：
10.1517/13543776.18.9.1091
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bifunctional aromatic compounds that contain both beta(2) agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to both activities and appear designed to provide a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease.
引用
收藏
页码：1091 / 1096
页数：6
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