Phase Transfer Catalysis Extends The Scope of The Algar-Flynn-Oyamada Synthesis of 3-Hydroxyflavones

被引：7

作者：

Duong Nhu ^{[1
,2
]}

Hawkins, Bill C. ^{[1
,2
]}

Burns, Christopher J. ^{[1
,2
,3
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, ACRF Chem Biol Div, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3010, Australia

[3] Univ Melbourne, Sch Chem, Inst Bio21, Melbourne, Vic 3010, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2015年 / 68卷 / 07期

基金：

英国医学研究理事会;

关键词：

DERIVATIVES; ANTICANCER; FLAVONOIDS; PHOTOCYCLOADDITION; INHIBITORS; CHALCONES; CHROMONES; LIBRARY; ANALOGS;

D O I：

10.1071/CH14620

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Algar-Flynn-Oyamada reaction is the classical method to synthesize 3-hydroxyflavones from chalcones. Despite its relative simplicity, the reaction has several drawbacks including variable and often low product yields. We have found that phase transfer catalysis improves the yields and expands the scope of the Algar-Flynn-Oyamada reaction of a series of 4-benzyloxy-2-hydroxy chalcones.

引用

页码：1102 / 1107

页数：6

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