High-throughput combinatorial synthesis of substituted benzimidazolones

被引：32

作者：

Pan, PC ^{[1
]}

Sun, CM ^{[1
]}

机构：

[1] Natl Dong Hwa Univ, Dept Chem, Shoufeng 974, Hualien, Taiwan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(99)01276-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient liquid-phase synthesis of substituted benzimidazolones 7 is described. Resin bound o-fluoronitrobenzene 1 is reacted with various primary amines to afford o-nitroaniline derivatives 2. Subsequent reduction of the aromatic nitro group followed by cyclization gives a PEG bound benzimidazole-2-one 4. N-Alkylation of this resin bound scaffold 4 with several electrophiles gives the resulting library in excellent yield and purity after cleavage. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6443 / 6446

页数：4

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