Design of New Amino Tf-Amide Organocatalysts: Environmentally Benign Approach to Asymmetric Aldol Synthesis

被引：13

作者：

Lee, Hyo-Jun ^{[1
]}

Arumugam, Natarajan ^{[2
]}

Almansour, Abdulrahman I. ^{[2
]}

Kumar, Raju Suresh ^{[2
]}

Maruoka, Keiji ^{[1
,3
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

[2] King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia

[3] Guangdong Univ Technol, Sch Chem Engn & Light Ind, HEMC, 100 West Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 04期

关键词：

asymmetric synthesis; aldol reaction; organocatalyst; brine; Mannich reaction; DIFFERENT PSEUDOENANTIOMERIC ORGANOCATALYSTS; MANNICH REACTIONS; EFFICIENT ORGANOCATALYST; PRACTICAL SYNTHESIS; SULFONAMIDE; ALDEHYDES; WATER;

D O I：

10.1055/s-0037-1610408

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new type of optically pure primary amino aromatic Tf-amide organocatalyst can be easily prepared from 8-amino-1-tetralone, and its chemical behavior was investigated in the context of asymmetric aldol and Mannich reactions. Most notably, the asymmetric aldol reaction proceeded smoothly in brine.

引用

页码：401 / 404

页数：4

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