Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

被引：10

作者：

El Maddah, Fayrouz ^{[1
,2
]}

Eguereva, Ekaterina ^{[1
]}

Kehraus, Stefan ^{[1
]}

Koenig, Gabriele M. ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut Biol, Nussallee 6, D-53115 Bonn, Germany

[2] Natl Org Drug Control & Res, Dept Pharmacognosy & Tissue Culture, Cairo, Egypt

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 10期

关键词：

A-C; METABOLITES; ACID; PROPIONATE; PRODUCTS; PHTHALIDES; PATHWAY; ORIGIN;

D O I：

10.1039/c9ob00198k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using C-13-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.

引用

页码：2747 / 2752

页数：6

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