Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients

被引：0
|
作者：
DelloStrologo, L
Massella, L
Rizzoni, G
机构：
来源：
PEDIATRIC NEPHROLOGY | 1996年 / 10卷 / 01期
关键词：
cyclosporine; acute hemodynamic effect renal; transplantation;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.
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页码：81 / 83
页数：3
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