Measurement of solubility of mitomycin C in ethanol-water solutions at different temperatures

被引：15

作者：

Gandhi, Pankaj J. ^{[1
]}

Murthy, Z. V. P. ^{[1
]}

机构：

[1] SV Natl Inst Technol, Dept Chem Engn, Surat 395007, Gujarat, India

来源：

THERMOCHIMICA ACTA | 2012年 / 545卷

关键词：

Mitomycin C; Ethanol-water mixture; Co-solvent; Solubility; ENTHALPY-ENTROPY COMPENSATION; PLUS WATER; COSOLVENT MIXTURES; MIXED-SOLVENTS; SALICYLIC-ACID; BEHAVIOR; DRUGS; THERMODYNAMICS; STREPTOMYCES; FIBROBLASTS;

D O I：

10.1016/j.tca.2012.07.014

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Solubility of mitomycin C drug in ethanol-water solutions was measured at different temperatures (0-50 degrees C) using high performance liquid chromatography. It was observed that the solubility of mitomycin C increases with temperature up to certain concentration of ethanol-water, after that it reduces due to several solute-solvent actions. The process is quite useful for developing nano-crystals of mitomycin C by changing the concentration of co-solvent mixture. From the observations of the present study, it may be suggested that for cardiovascular, ophthamalic and cancer applications of mitomycin C one can use ethanol-water co-solvent mixture for deriving nano-crystals. A modified Apelblat equation was used to correlate the experimental data. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：163 / 173

页数：11

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