Data on Wistar Hannover Rats from a General Toxicity Study

被引：4

作者：

Yamatoya, Hideyuki ^{[1
,2
,4
]}

Kawaguchi, Hiroaki ^{[1
,2
]}

Yajima, Kanako ^{[5
]}

Kadokura, Hidetomi ^{[4
]}

Yoshikawa, Tsuyoshi ^{[4
]}

Yamashita, Rie ^{[4
]}

Shiraishi, Mitsuya ^{[2
,3
]}

Miyamoto, Atsushi ^{[2
,3
]}

Miyoshi, Noriaki ^{[1
,2
]}

机构：

[1] Kagoshima Univ, Dept Vet Histopathol, Joint Fac Vet Med, Kagoshima 8900065, Japan

[2] Yamaguchi Univ, United Grad Sch Vet Sci, Yamaguchi 7538515, Japan

[3] Kagoshima Univ, Dept Vet Pharmacol, Joint Fac Vet Med, Kagoshima 8900065, Japan

[4] Shin Nippon Biomed Labs Ltd SNBL DSR, Drug Safety Res Labs, Kagoshima 8911394, Japan

[5] Shin Nippon Biomed Labs Ltd SNBL PBC, Pharmacokinet & Bioanal Ctr, Wakayama 6420017, Japan

来源：

EXPERIMENTAL ANIMALS | 2012年 / 61卷 / 04期

关键词：

clinical laboratory test; hepatic drug-metabolizing enzyme; pathological examination; SPRAGUE-DAWLEY RATS; LIVER MICROSOMES; SEX; BINDING; MICE;

D O I：

10.1538/expanim.61.467

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.

引用

页码：467 / 476

页数：10

共 50 条

[31] CHRONIC TOXICITY OF CORDEMCURA IN WISTAR RATS
ZSCHORN, EM
STADE, K
JANOWSKI, K
PHARMAZIE, 1986, 41 (03): : 210 - 211
[32] Developmental Toxicity of Homobrassinolide in Wistar Rats
Murkunde, Yogeshkumar V.
Murthy, P. Balakrishna
INTERNATIONAL JOURNAL OF TOXICOLOGY, 2010, 29 (05) : 517 - 522
[33] Sub-acute Toxicity Study and Toxicity Reversibility of Ayabirungarajakarpamin Wistar Albino Rats
Varnakulendran, Nagalingam
Elango, Veeriah
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2021, 11 (04): : P33 - P41
[34] Histopathological and immunohistochemical characterization of spontaneous pituitary tumors in dwarfs derived from Wistar Hannover GALAS rats
Kokoshima, Hiroko
Yamada, Naoaki
Doi, Takuya
Tsuchitani, Minoru
Yamate, Jyoji
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2016, 68 (2-3) : 191 - 196
[35] Subchronic Inhalation Toxicity Study of Methylchloroisothiazolinone/Methylisothiazolinone Mixture in Wistar Rats
Choi, S-. J.
Heo, Y.
Bae, S-. H.
Seo, G.
Lee, K.
INTERNATIONAL JOURNAL OF TOXICOLOGY, 2019, 38 (01) : 35 - 35
[36] A toxicity study of simultaneous administration of Tamoxifen® and Diazepam® to female Wistar rats
D'Mello, D
Mehta, D
Pereira, J
Rao, CV
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 1999, 51 (06) : 549 - 553
[37] Prenatal developmental toxicity study of n-heneicosane in Wistar rats
Kumar, Pravin
Lomash, Vinay
Jatav, P. C.
Kumar, A.
Pant, S. C.
TOXICOLOGY AND INDUSTRIAL HEALTH, 2016, 32 (01) : 118 - 125
[38] Acute and sub-chronic toxicity study of diaveridine in Wistar rats
Wang, Xu
Su, Shijia
Ihsan, Awais
Huang, Qin
Chen, Dongmei
Cheng, Guyue
Liu, Zhenli
Wang, Yulian
Yuan, Zonghui
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 73 (01) : 232 - 240
[39] A subtoxic interactive toxicity study of ethanol and chromium in male Wistar rats
Acharya, S
Mehta, K
Krishnan, S
Rao, CV
ALCOHOL, 2001, 23 (02) : 99 - 108
[40] Study of the toxicity and efficacy in Wistar rats of a phytoterapic used as sedative and/or hypnotic
de Mello, Fernanda Bastos
Langeloh, Augusto
de Mello, Joao Roberto Braga
LATIN AMERICAN JOURNAL OF PHARMACY, 2007, 26 (01): : 38 - 44

← 1 2 3 4 5 →