DZNep attenuates liver fibrosis by blocking EZH2 and H3K27me3

被引:0
|
作者
Zeybel, Mujdat [1 ]
Walsh, Meagan J. [1 ]
Chu, David C. [2 ]
Tsukamoto, Hidekazu [3 ]
Mann, Derek A. [1 ]
Mann, Jelena [1 ]
机构
[1] Newcastle Univ, Liver Res Grp, ICM, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Univ Georgia, Coll Pharm Pharmaceut & Biomed Sci, Athens, GA 30602 USA
[3] Univ So Calif, Keck Sch Med, Los Angeles, CA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
1216
引用
收藏
页码:772A / 772A
页数:1
相关论文
共 50 条
  • [41] The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
    Yamato Fukui
    Yasushi Hirota
    Shizu Aikawa
    Akihiko Sakashita
    Ryoko Shimizu-Hirota
    Norihiko Takeda
    Chihiro Ishizawa
    Rei Iida
    Tetsuaki Kaku
    Tomoyuki Hirata
    Takehiro Hiraoka
    Shun Akaeda
    Mitsunori Matsuo
    Yutaka Osuga
    Cell Death & Disease, 14
  • [42] Epigenetic Modifications in Cutaneous Malignant Melanoma: EZH2, H3K4me2, and H3K27me3 Immunohistochemical Expression is Enhanced at the Invasion Front of the Tumor
    Kampilafkos, Panagiotis
    Melachrinou, Maria
    Kefalopoulou, Zinovia
    Lakoumentas, John
    Sotiropoulou-Bonikou, Georgia
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2015, 37 (02) : 138 - 144
  • [43] EZH2-mediated H3K27me3 inhibits ACE2 expression
    Li, Yuanyuan
    Li, Honggang
    Zhou, Liquan
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 526 (04) : 947 - 952
  • [44] Altered expression of epigenetic modifiers EZH2, H3K27me3, and DNA methyltransferases in meningiomas - prognostic biomarkers for routine practice
    Samal, Swagatika
    Patnaik, Ashis
    Sahu, Fakir Mohan
    Purkait, Suvendu
    FOLIA NEUROPATHOLOGICA, 2020, 58 (02) : 133 - 142
  • [45] Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells
    French, B. A.
    Oliva, J.
    Bardag-Gorce, F.
    Li, J.
    Zhong, J.
    Buslon, V.
    French, S. W.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2012, 92 (03) : 318 - 326
  • [46] EZH2 Promotes Corneal Endothelial Cell Apoptosis by Mediating H3K27me3 and Inhibiting HO-1 Transcription
    Lin, Ying
    Su, Huanjun
    Zou, Baoyi
    Huang, Minli
    CURRENT EYE RESEARCH, 2023, 48 (12) : 1122 - 1132
  • [47] EZH2 suppresses insulinoma development by epigenetically reducing KIF4A expression via H3K27me3 modification
    Zhang, Suzhen
    Liu, Jun
    Li, Feng
    Yang, Mudan
    Wang, Junping
    GENE, 2022, 822
  • [48] Aberrant overexpression of EZH2 and H3K27me3 serves as poor prognostic biomarker for esophageal squamous cell carcinoma patients
    Liu, Fei
    Gu, Lina
    Cao, Yu
    Fan, Xiaojie
    Zhang, Fengjuan
    Sang, Meixiang
    BIOMARKERS, 2016, 21 (01) : 80 - 90
  • [49] EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition
    Romero, Pierre
    Richart, Laia
    Aflaki, Setareh
    Petitalot, Ambre
    Burton, Megan
    Michaud, Audrey
    Masliah-Planchon, Julien
    Kuhnowski, Frederique
    Le Cam, Samuel
    Balinas-Gavira, Carlos
    Meaudre, Celine
    Luscan, Armelle
    Hamza, Abderaouf
    Legoix, Patricia
    Vincent-Salomon, Anne
    Wassef, Michel
    Holoch, Daniel
    Margueron, Raphael
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [50] Evaluation of H3K27me3 Expression as a Marker of EZH2 Activation in SMARCA4/SMARCA2-Deficient Tumors and Candidate Biomarker for Trials of EZH2 Inhibitors
    Kezlarian, Brie
    Montecalvo, Joseph
    Sauter, Jennifer
    Travis, William
    Gounder, Mrinal
    Rudin, Charles
    Ladanyi, Marc
    Namakydoust, Azadeh
    Rekhtman, Natasha
    LABORATORY INVESTIGATION, 2019, 99