A novel zinc-catalyzed Suzuki-type cross-coupling reaction of aryl boronic acids with alkynyl bromides

被引：25
|
作者：
Krishnan, K. Keerthi [1 ]
Saranya, Salim [1 ]
Rohit, K. R. [1 ]
Anilkumar, Gopinathan [1 ]
机构：
[1] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India
来源：
JOURNAL OF CATALYSIS | 2019年 / 372卷
关键词：
Zinc catalysis; Suzuki coupling; Cross-coupling; Boronic acids; Bromides; TERMINAL ALKYNES; SONOGASHIRA; PERSPECTIVES; IODIDES; HALIDES; PROTOCOL; COMPLEXES; WATER;
D O I：
10.1016/j.jcat.2019.03.005
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel Suzuki-type cross-coupling reaction of organoboron reagents with alkynyl bromides has been developed in the presence of catalytic Et2Zn/DMEDA system. The reaction afforded a variety of internal alkynes in moderate to excellent yields under mild reaction conditions without the formation of any homo-coupling products. The resulting internal alkynes have valuable applications in pharmaceutical and industrial areas. The use of relatively non-toxic zinc, chelating amine ligand and low reaction temperature make this protocol an alternative for the synthesis of internal alkynes. The scope and limitations of this protocol are also investigated. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：266 / 271
页数：6
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